Orlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female Rats

Obesity has been linked to several chronic diseases, including fatty liver disease, heart diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was determine how Orlistat affected renal toxicity, DNA damage, apoptosis that were brought on by obesity in normal obese female rats. There four groups made up a total 20 rats (G1, Control; G2, Orlistat; G3, Obesity; G4, treated with rat group). results present investigation showed orlistat treatment resulted kidney injury, P53 mutations as well large increase serum urea creatinine levels significant drop sodium, potassium, calcium, chloride ions levels. Therefore, when administered treat or rats, caused damage; result, doctors should carefully monitor it.